Diffusion-weighted magnetic resonance imaging in metastatic gastrointestinal stromal tumor (GIST): a pilot study on the assessment of treatment response in comparison with 18F-FDG PET/CT.

Détails

ID Serval
serval:BIB_4310547DD0F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diffusion-weighted magnetic resonance imaging in metastatic gastrointestinal stromal tumor (GIST): a pilot study on the assessment of treatment response in comparison with 18F-FDG PET/CT.
Périodique
Acta radiologica (Stockholm, Sweden : 1987)
Auteur(s)
Schmidt S., Dunet V., Koehli M., Montemurro M., Meuli R., Prior J.O.
ISSN
1600-0455 (Electronic)
ISSN-L
0284-1851
Statut éditorial
Publié
Date de publication
10/2013
Peer-reviewed
Oui
Volume
54
Numéro
8
Pages
837-842
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
Diffusion-weighted magnetic resonance imaging (MRI) is increasingly being used for assessing the treatment succes in oncology, but the real clinical value needs to evaluated by comparison with other, already established, metabolic imaging techniques.
To prospectively evaluate the clinical potential of diffusion-weighted MRI with apparent diffusion coefficient (ADC) mapping for gastrointestinal stromal tumor (GIST) response to targeted therapy compared with 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).
Eight patients (mean age, 56 ± 11 years) known to have metastatic GIST underwent 18F-FDG PET/CT and MRI (T1Gd, DWI [b = 50,300,600], ADC mapping) simultaneously, before and after change in targeted therapy. MR and PET/CT examinations were first analyzed blindly. Second, PET/CT images were co-registered with T1Gd-MR images for lesion detection. Only 18F-FDG avid lesions were considered. Maximum standardized uptake value (SUVmax) and the corresponding minimum ADCmin were measured for the six largest lesions per patient, if any, on baseline and follow-up examinations. The relationship between changes in SUVmax and ADCmin was analyzed (Spearman's correlation).
Twenty-four metastases (12 hepatic, 12 extra-hepatic) were compared on PET/CT and MR images. SUVmax decreased from 7.7 ± 8.1 g/mL to 5.5 ± 5.4 g/mL (P = 0.20), while ADCmin increased from 1.2 ± 0.3 × 10(-3)mm(2)/s to 1.5 ± 0.3 × 10(-3)mm(2)/s (P = 0.0002). There was a significant association between changes in SUVmax and ADCmin (rho = - 0.62, P = 0.0014), but not between changes in lesions size (P = 0.40).
Changes in ADCmin correlated with the response of 18F-FDG avid GIST to targeted therapy. Thus, diffusion-weighted MRI may represent a radiation-free alternative for follow-up treatment for metastatic GIST patients.

Mots-clé
Contrast Media, Diffusion Magnetic Resonance Imaging/methods, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Gastrointestinal Neoplasms/diagnosis, Gastrointestinal Neoplasms/pathology, Gastrointestinal Neoplasms/secondary, Gastrointestinal Stromal Tumors/diagnosis, Gastrointestinal Stromal Tumors/pathology, Humans, Image Enhancement/methods, Image Processing, Computer-Assisted/methods, Imaging, Three-Dimensional/methods, Liver Neoplasms/diagnosis, Liver Neoplasms/secondary, Male, Meglumine, Middle Aged, Multimodal Imaging/methods, Observer Variation, Organometallic Compounds, Pilot Projects, Prospective Studies, Radiopharmaceuticals, Reproducibility of Results, Treatment Outcome, 18F-FDG PET/CT, Gastrointestinal stromal tumor (GIST), MR diffusion imaging, apparent diffusion coefficient (ADC), standard uptake value (SUV)
Pubmed
Web of science
Création de la notice
08/07/2013 15:41
Dernière modification de la notice
03/03/2018 16:39
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