Apoptosis time course in the limbic system after myocardial infarction in the rat

Détails

ID Serval
serval:BIB_42E9EDCBC59D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Apoptosis time course in the limbic system after myocardial infarction in the rat
Périodique
Brain Res
Auteur(s)
Kaloustian S., Wann B. P., Bah T. M., Girard S. A., Apostolakis A., Ishak S., Mathieu S., Ryvlin P., Godbout R., Rousseau G.
ISSN
0006-8993 (Print)
ISSN-L
0006-8993
Statut éditorial
Publié
Date de publication
2008
Volume
1216
Pages
87-91
Langue
anglais
Notes
Kaloustian, S
Wann, B P
Bah, T M
Girard, S A
Apostolakis, A
Ishak, S
Mathieu, S
Ryvlin, P
Godbout, R
Rousseau, G
eng
Comparative Study
Research Support, Non-U.S. Gov't
Netherlands
Brain Res. 2008 Jun 24;1216:87-91. doi: 10.1016/j.brainres.2008.04.019. Epub 2008 Apr 18.
Résumé
Apoptosis is known to occur in the limbic system after myocardial infarction (MI) in the rat. Our study was designed to evaluate the time course dynamics of this phenomenon in limbic areas. Apoptosis, i.e., caspase-3 activity and the number of terminal dUTP nick-end labelling-positive cells, as well as brain-derived neurotrophic factor (BDNF) were quantitated in sham-operated controls and MI rats 1, 2 and 7 days after surgery. Both apoptosis parameters were increased throughout, although in different structures: the CA1 region of the hippocampus and the medial amygdala at day 1, the CA1 region of the hippocampus and the lateral amygdala at day 2, and the frontal cortex at day 7. At day 2, BDNF was decreased in the prefrontal cortex and medial amygdala, whereas it was elevated in the dentate gyrus of the hippocampus; at day 7, BDNF was reduced in the frontal cortex and posterior hypothalamus but was augmented in the medial amygdala. These data indicate that post-MI apoptosis in the limbic system is a dynamic process occurring mainly in the hippocampus and amygdala during the first days after MI. The fact that BDNF was increased as early as 2 days after MI suggests that neurogenesis can occur rapidly in selected limbic regions after MI.
Mots-clé
Amygdala/metabolism/*pathology, Animals, Apoptosis/*physiology, Brain-Derived Neurotrophic Factor/metabolism, Caspase 3/metabolism, Hippocampus/metabolism/*pathology, Limbic System/metabolism/pathology, Male, Myocardial Infarction/*pathology, Neurons/metabolism/pathology, Rats, Rats, Sprague-Dawley, Time Factors, Tissue Distribution
Pubmed
Création de la notice
29/11/2018 13:36
Dernière modification de la notice
12/01/2019 7:26
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