Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy.

Détails

ID Serval
serval:BIB_42E090DFCA70
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy.
Périodique
The Journal of investigative dermatology
Auteur(s)
Meylan P., Lang C., Mermoud S., Johannsen A., Norrenberg S., Hohl D., Vial Y., Prod'hom G., Greub G., Kypriotou M., Christen-Zaech S.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Statut éditorial
Publié
Date de publication
12/2017
Peer-reviewed
Oui
Volume
137
Numéro
12
Pages
2497-2504
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Atopic dermatitis (AD) has a well-established association with skin colonization or infection by Staphylococcus aureus, which can exacerbate the disease. However, a causal relationship between specific changes in skin colonization during the first years of life and AD development still remains unclear. In this prospective birth cohort study, we aimed to characterize the association between skin colonization and AD development in 149 white infants with or without a family history of atopy. We assessed infants clinically and collected axillary and antecubital fossa skin swabs for culture-based analysis at birth and at seven time points over the first 2 years of life. We found that at age 3 months, S. aureus was more prevalent on the skin of infants who developed AD later on. S. aureus prevalence was increased on infants' skin at the time of AD onset and also 2 months before it, when compared with age-matched, unaffected infants. Furthermore, at AD onset, infants testing positive for S. aureus were younger than uncolonized subjects. In conclusion, our results suggest that specific changes in early-life skin colonization may actively contribute to clinical AD onset in infancy.

Mots-clé
Dermatitis, Atopic/complications, Dermatitis, Atopic/drug therapy, Dermatitis, Atopic/microbiology, Eczema/complications, Eczema/drug therapy, Eczema/microbiology, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Skin/microbiology, Staphylococcal Infections/complications, Staphylococcal Infections/drug therapy, Staphylococcus aureus, Vagina/microbiology
Pubmed
Web of science
Création de la notice
12/09/2017 14:59
Dernière modification de la notice
03/03/2018 16:39
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