Corticotropin releasing factor activity of CRF 41 in normal man is potentiated by angiotensin II and vasopressin but not by desmopressin

Détails

ID Serval
serval:BIB_42D7CADA81D6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Corticotropin releasing factor activity of CRF 41 in normal man is potentiated by angiotensin II and vasopressin but not by desmopressin
Périodique
Life Sciences
Auteur(s)
Gaillard  R. C., Riondel  A. M., Ling  N., Muller  A. F.
ISSN
0024-3205 (Print)
Statut éditorial
Publié
Date de publication
1988
Volume
43
Numéro
23
Pages
1935-44
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Résumé
Multiple hypothalamic factors seem to influence ACTH release. In vitro and/or in vivo animal models have shown that angiotensin II, vasopressin and some of its analogs are ACTH secretagogues capable of potentiating the corticotropin releasing activity of CRF41. Since these effects are controversial in man, we investigated in 3 groups of volunteers the corticotropin releasing activity of a 2h-infusion of angiotensin II (7 ng/kg/min), vasopressin (1 ng/kg/min) and desmopressin (1 ng/kg/min) given alone or in combination with a bolus injection of 100 micrograms CRF41 by measuring plasma concentrations of ACTH, cortisol, dehydroepiandrosterone and delta 4-androstenedione. Given alone angiotensin II and desmopressin had no significant effect in contrast to vasopressin which increased significantly the ACTH and steroid levels. Angiotensin II and vasopressin were both able to potentiate the corticotropin releasing activity of CRF41, whereas desmopressin was unable to produce such a potentiation. These results suggest that in man vasopressin and angiotensin II may well regulate the responsiveness of the pituitary-adrenal axis in various physiological or pathophysiological situations.
Mots-clé
Adrenocorticotropic Hormone/blood Adult Androstenedione/blood Angiotensin II/adverse effects/*pharmacology Corticotropin-Releasing Hormone/adverse effects/*pharmacology Deamino Arginine Vasopressin/adverse effects/*pharmacology Dehydroepiandrosterone/blood Drug Synergism Humans Hydrocortisone/blood Kinetics Male Vasopressins/adverse effects/*pharmacology
Pubmed
Web of science
Création de la notice
15/02/2008 17:58
Dernière modification de la notice
03/03/2018 16:39
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