Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Apoptotic markers in protozoan parasites.
Parasites and Vectors
ABSTRACT: The execution of the apoptotic death program in metazoans is characterized by a sequence of morphological and biochemical changes that include cell shrinkage, presentation of phosphatidylserine at the cell surface, mitochondrial alterations, chromatin condensation, nuclear fragmentation, membrane blebbing and the formation of apoptotic bodies. Methodologies for measuring apoptosis are based on these markers. Except for membrane blebbing and formation of apoptotic bodies, all other events have been observed in most protozoan parasites undergoing cell death. However, while techniques exist to detect these markers, they are often optimised for metazoan cells and therefore may not pick up subtle differences between the events occurring in unicellular organisms and multi-cellular organisms.In this review we discuss the markers most frequently used to analyze cell death in protozoan parasites, paying special attention to changes in cell morphology, mitochondrial activity, chromatin structure and plasma membrane structure/permeability. Regarding classical regulators/executors of apoptosis, we have reviewed the present knowledge of caspase-like and nuclease activities.
PROGRAMMED CELL-DEATH, LEISHMANIA-DONOVANI PROMASTIGOTES, TRYPANOSOMA-BRUCEI-RHODESIENSE, MILTEFOSINE INDUCES APOPTOSIS, ASEXUAL BLOOD STAGES, BCL-X-L, PLASMODIUM-FALCIPARUM, DNA FRAGMENTATION, BLASTOCYSTIS-HOMINIS, FEBRILE TEMPERATURE
Web of science
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