Aminergic Signaling Controls Ovarian Dormancy in Drosophila.

Détails

Ressource 1Télécharger: s41598-018-20407-z.pdf (7041.87 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_42B4FE08AC2D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Aminergic Signaling Controls Ovarian Dormancy in Drosophila.
Périodique
Scientific reports
Auteur(s)
Andreatta G., Kyriacou C.P., Flatt T., Costa R.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
01/02/2018
Peer-reviewed
Oui
Volume
8
Numéro
1
Pages
2030
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. elegans and in several insects, but how neurosensory mechanisms act to relay environmental cues to the endocrine system in order to induce dormancy remains unclear. Here we examine this fundamental question by genetically manipulating aminergic neurotransmitter signaling in Drosophila melanogaster. We find that both serotonin and dopamine enhance adult ovarian dormancy, while the downregulation of their respective signaling pathways in endocrine cells or tissues (insulin producing cells, fat body, corpus allatum) reduces dormancy. In contrast, octopamine signaling antagonizes dormancy. Our findings enhance our understanding of the ability of organisms to cope with unfavorable environments and illuminate some of the relevant signaling pathways.
Mots-clé
Animals, Dopamine/metabolism, Drosophila, Endocrine Cells/metabolism, Female, Octopamine/metabolism, Ovary/growth & development, Ovary/metabolism, Serotonin/metabolism, Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/02/2018 16:52
Dernière modification de la notice
20/08/2019 14:45
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