Obsessional slowness. Functional studies with positron emission tomography.

Détails

ID Serval
serval:BIB_42B4DEB36D3C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Obsessional slowness. Functional studies with positron emission tomography.
Périodique
Brain
Auteur(s)
Sawle G.V., Hymas N.F., Lees A.J., Frackowiak R.S.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
1991
Volume
114 ( Pt 5)
Pages
2191-2202
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Patients with Obsessional Slowness (OS) exhibit extreme slowness in the execution of some everyday tasks, such as washing and eating. This may be due to time-consuming rituals, checking behaviour and compulsions. On examination some have neurological signs such as a glabellar tap reflex, cogwheel rigidity or abnormal postures. The purpose of this study was to establish a functional explanation for slowness in this patient group. We have studied 6 OS patients using positron emission tomography (PET) with (15)Oxygen to measure regional cerebral oxygen metabolism and [18F]-6-Fluorodopoa (18F-dopa) to assess the integrity of the presynaptic nigrostriatal system. The findings were of focal hypermetabolism in orbital frontal, premotor and midfrontal cortex, whilst dopa uptake into caudate, putamen and medial frontal cortex was normal. The relationship of these findings to the patients' slowness is discussed.
Mots-clé
Adult, Brain/metabolism, Brain/radionuclide imaging, Compulsive Behavior/metabolism, Dihydroxyphenylalanine/metabolism, Fluorine Radioisotopes/diagnostic use, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder/metabolism, Oxygen/metabolism, Time Factors, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
25/09/2011 17:40
Dernière modification de la notice
03/03/2018 16:38
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