Orodigital pemphigus vulgaris : a pathogenic role of anti-desmoglein-3 autoantibodies in pemphigus paronychia?

Détails

ID Serval
serval:BIB_42A1166386FD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Orodigital pemphigus vulgaris : a pathogenic role of anti-desmoglein-3 autoantibodies in pemphigus paronychia?
Périodique
Dermatology
Auteur(s)
Laffitte E., Panizzon R.G., Borradori L.
ISSN
1018-8665
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
217
Numéro
4
Pages
337-339
Langue
anglais
Résumé
Paronychia is a rare complication of pemphigus vulgaris (PV), and the immunological profile of patients with digital disease has not been assessed so far. We report 2 cases of PV with oral mucosa and periungual involvement, who had high titers of anti- desmoglein (Dsg)-3 circulating antibodies. These observations raise the possibility that expression of Dsg-1 and Dsg-3 in distinct areas of periungual skin is disease specific and that anti-Dsg-3 antibodies alone may have an as yet unrecognized importance for the development of paronychia in PV.
Mots-clé
Aged, Autoantibodies/blood, Biological Markers/blood, Desmoglein 1/immunology, Desmoglein 3/immunology, Enzyme-Linked Immunosorbent Assay, Female, Fingers, Humans, Middle Aged, Mouth Diseases/immunology, Mouth Diseases/pathology, Mouth Mucosa/pathology, Paronychia/immunology, Pemphigus/immunology, Pemphigus/pathology, Toes
Pubmed
Web of science
Création de la notice
15/10/2009 9:06
Dernière modification de la notice
03/03/2018 16:38
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