Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Orodigital pemphigus vulgaris : a pathogenic role of anti-desmoglein-3 autoantibodies in pemphigus paronychia?
Paronychia is a rare complication of pemphigus vulgaris (PV), and the immunological profile of patients with digital disease has not been assessed so far. We report 2 cases of PV with oral mucosa and periungual involvement, who had high titers of anti- desmoglein (Dsg)-3 circulating antibodies. These observations raise the possibility that expression of Dsg-1 and Dsg-3 in distinct areas of periungual skin is disease specific and that anti-Dsg-3 antibodies alone may have an as yet unrecognized importance for the development of paronychia in PV.
Aged, Autoantibodies/blood, Biological Markers/blood, Desmoglein 1/immunology, Desmoglein 3/immunology, Enzyme-Linked Immunosorbent Assay, Female, Fingers, Humans, Middle Aged, Mouth Diseases/immunology, Mouth Diseases/pathology, Mouth Mucosa/pathology, Paronychia/immunology, Pemphigus/immunology, Pemphigus/pathology, Toes
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