Clinical uses of anti-Mullerian hormone assays: pitfalls and promises

Détails

ID Serval
serval:BIB_4264E0ABF7FB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clinical uses of anti-Mullerian hormone assays: pitfalls and promises
Périodique
Fertility and Sterility
Auteur(s)
Streuli  I., Fraisse  T., Chapron  C., Bijaoui  G., Bischof  P., de Ziegler  D.
ISSN
1556-5653
Statut éditorial
Publié
Date de publication
02/2008
Peer-reviewed
Oui
Notes
Journal article --- Old month value: Feb 2
Résumé
OBJECTIVE: To investigate whether the controversy about fluctuations of anti-Mullerian hormone (AMH) levels during the menstrual cycle results from differences between the immunoassays currently available: the Beckman Coulter Immunotech kit (Fullerton, CA) and the Diagnostic Systems Laboratories kit (Webster, TX). DESIGN: Prospective trial. SETTING: Fertility clinics of two tertiary university hospitals. PATIENT(S): One hundred sixty-eight blood samples from three different populations. Serial samples at set intervals from the LH surge were taken in a fourth population of 10 volunteers. INTERVENTION(S): We remeasured AMH levels by using the Diagnostic Systems Laboratories kit in 168 blood samples in which AMH initially had been measured by using the Beckman Coulter assay. We also conducted serial AMH measurements (n = 7) during the menstrual cycle of 10 women. MAIN OUTCOME MEASURE(S): Linear regression of AMH levels determined by using 2 different assays and analysis of variance of serial measurements in the menstrual cycle. RESULT(S): We found a linear relationship between the 2 methods, with a correlation coefficient of 0.88. When repeated individual AMH measures were longitudinally analyzed in relation to the LH surge, a slight but significant decrease was observed after ovulation. CONCLUSION(S): Differences in AMH fluctuations during the menstrual cycle reported in recent publications do not result from the use of different AMH assays. The changes in AMH levels after ovulation are slight, yet statistically significant. However, the fluctuations observed are smaller than intercycle variability and therefore are not clinically relevant as far as AMH measurements for clinical purposes are concerned. In daily practice, AMH therefore can be measured anytime during the menstrual cycle.
Pubmed
Web of science
Création de la notice
28/02/2008 12:37
Dernière modification de la notice
03/03/2018 16:37
Données d'usage