Effects of dexamethasone on hepatic glucose production and fructose metabolism in healthy humans.

Détails

ID Serval
serval:BIB_424FEC4B7C99
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effects of dexamethasone on hepatic glucose production and fructose metabolism in healthy humans.
Périodique
American Journal of Physiology. Endocrinology and Metabolism
Auteur(s)
Tounian P., Schneiter P., Henry S., Delarue J., Tappy L.
ISSN
0193-1849 (Print)
ISSN-L
0002-9513
Statut éditorial
Publié
Date de publication
1997
Volume
273
Numéro
2 Pt 1
Pages
E315-E320
Langue
anglais
Résumé
This study was designed to determine whether glucocorticoids alter autoregulation of glucose production and fructose metabolism. Two protocols with either dexamethasone (DEX) or placebo (Placebo) were performed in six healthy men during hourly ingestion of[13C]fructose (1.33 mmol.kg-1.h-1) for 3 h. In both protocols, endogenous glucose production (EGP) increased by 8 (Placebo) and 7% (DEX) after fructose, whereas gluconeogenesis from fructose represented 82 (Placebo) and 72% (DEX) of EGP. Fructose oxidation measured from breath 13CO2 was similar in both protocols [9.3 +/- 0.7 (Placebo) and 9.6 +/- 0.5 mumol.kg-1.min-1 (DEX)]. Nonoxidative carbohydrate disposal, calculated as fructose administration rate minus net carbohydrate oxidation rate after fructose ingestion measured by indirect calorimetry, was also similar in both protocols [5.8 +/- 0.8 (Placebo) and 5.9 +/- 2.0 mumol.kg-1.min-1 (DEX)]. We concluded that dexamethasone 1) does not alter the autoregulatory process that prevents a fructose-induced increase in gluconeogenesis from increasing total glucose production and 2) does not affect oxidative and nonoxidative pathways of fructose. This indicates that the insulin-regulated enzymes involved in these pathways are not affected in a major way by dexamethasone.
Mots-clé
Adult, Carbon Dioxide, Dexamethasone/pharmacology, Energy Metabolism, Fructose/metabolism, Glucocorticoids/pharmacology, Glucose/biosynthesis, Glucose/metabolism, Hormones/blood, Humans, Kinetics, Liver/metabolism, Male, Oxidation-Reduction, Reference Values, Respiration, Substrate Specificity
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
03/03/2018 16:36
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