Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner

Détails

ID Serval
serval:BIB_424AFB86F7A1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner
Périodique
Developmental Dynamics
Auteur(s)
Schouwey  K., Delmas  V., Larue  L., Zimber-Strobl  U., Strobl  L. J., Radtke  F., Beermann  F.
ISSN
1058-8388 (Print)
Statut éditorial
Publié
Date de publication
01/2007
Volume
236
Numéro
1
Pages
282-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
The Notch signaling pathway is involved in diverse biological processes such as cell fate decisions or stem cell maintenance. In this study, we assessed the role of this pathway for melanocyte development and hair pigmentation using RBP-Jkappa, Notch1, and Notch2 conditional knockout mice. Disruption of the Notch pathway by inactivating RBP-Jkappa in the melanocyte lineage using Tyr::Cre mice led to a severe coat color dilution. Similarly, hair graying was observed when Notch1 and/or Notch2 receptors were ablated in melanocytes. This phenotype was proportional to the number of floxed Notch alleles, with the most pronounced effect seen in Tyr::Cre/degrees; Notch1(flox/flox); Notch2(flox/flox) mice. Deletion of Notch1 and/or Notch2 in melanoblasts did not induce a congenital defect. The number of Dct-expressing cells at embryonic stages was not affected, but melanocytes located within the hair matrix progressively disappeared during the first regeneration of the hair follicle. In contrast, non-follicular melanocytes and pigmentation in the dermis and in the choroid were not affected. We suggest that both Notch1 and Notch2 receptors contribute to the maintenance of melanoblasts and melanocyte stem cells, and are essential for proper hair pigmentation.
Mots-clé
Alleles Animals Cell Lineage Embryo/metabolism Genotype Hair Color/*physiology Hair Follicle/embryology/*metabolism In Situ Hybridization Intramolecular Oxidoreductases/metabolism Melanocytes/metabolism Mice Mice, Knockout Mice, Transgenic Phenotype Receptor, Notch1/genetics/*metabolism Receptor, Notch2/genetics/*metabolism *Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:39
Dernière modification de la notice
08/05/2019 17:43
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