Article: article from journal or magazin.
Characterization of a cAMP-regulated enhancer-binding protein.
Metabolism: clinical and experimental
9 Suppl 2
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S. - Publication Status: ppublish
The transcription regulation of many hormone genes is modulated by intracellular second messengers such as cAMP. The cAMP response element binding protein, CREB, binds to the 8 base pair CRE enhancer, TGACGTCA, that is found in the 5'-flank of certain genes including those for somatostatin and the alpha-subunit of human chorionic gonadotropin. The recent characterization of CREB and CREB-related cDNA clones, combined with Southwesterns and Northern blot analyses, reveals a family of transcription factors that dimerize via a leucine zipper motif and bind to the CRE through positively charged basic regions. The CREB cDNA encoding a 327 residue protein is transcriptionally activated via phosphorylation by protein kinases, including the cAMP-dependent protein kinase-A.
Animals, Base Sequence, Cloning, Molecular, Cyclic AMP Response Element-Binding Protein, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, Female, Humans, Models, Biological, Molecular Sequence Data, Phosphorylation, Placenta, Protein Kinases, Transcription Factors
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