CD11b/CD18 expression, adherence, and chemotaxis of granulocyte in adult respiratory distress syndrome
Details
Serval ID
serval:BIB_420A4F68A18B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CD11b/CD18 expression, adherence, and chemotaxis of granulocyte in adult respiratory distress syndrome
Journal
American Journal of Respiratory and Critical Care Medicine
ISSN
1073-449X (Print)
Publication state
Published
Issued date
06/1994
Volume
149
Number
6
Pages
1534-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
The accumulation of granulocytes in the pulmonary microvasculature is generally thought a cardinal event in the pathology of adult respiratory distress syndrome (ARDS). However, the mechanism by which granulocytes are sequestered in the pulmonary vascular bed remains largely unknown. Because the CD11b/CD18 membrane receptors mediate various adhesion-dependent functions, their expression was investigated in granulocytes from patients during the course of ARDS development in relation to adherence and chemotaxis. CD11b expression of ARDS resting granulocytes was increased within 24 h of ARDS onset by a factor of two in comparison with control patients (p < 0.05) and remained significantly increased 72 to 120 h later. In contrast, the stimulated expression was significantly decreased only within 24 h of ARDS onset. Adherence was not modified within 8 h of the onset of ARDS, but was increased at Days 1, 3, and 5. The time course of granulocyte chemotaxis shows a decreased chemotaxis capacity during the first 3 d of ARDS, followed by normalization at Day 5. The dynamic changes observed in the various functions studied indicate a possible relationship between the modulation of the CD11b expression and a hyperadhesive state of granulocytes in ARDS. These sticky granulocytes may potentially contribute to the microvascular injury.
Keywords
Adult
Aged
*Antigens, CD/genetics/immunology
Antigens, CD11
Antigens, CD18
Case-Control Studies
Cell Adhesion
*Chemotaxis, Leukocyte/genetics/immunology
*Gene Expression
Granulocytes/immunology/*pathology
Humans
Middle Aged
N-Formylmethionine Leucyl-Phenylalanine
*Pulmonary Circulation
*Receptors, Leukocyte-Adhesion/genetics/immunology
Respiratory Distress Syndrome,
Adult/*blood/etiology/genetics/immunology/*pathology
Time Factors
Pubmed
Web of science
Create date
25/01/2008 10:38
Last modification date
20/08/2019 14:43