Macrofollicular variant of follicular thyroid carcinoma: a clinical, cytologic, morphologic, and image analysis study of a unique case.

Détails

ID Serval
serval:BIB_41F8FB62B607
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Macrofollicular variant of follicular thyroid carcinoma: a clinical, cytologic, morphologic, and image analysis study of a unique case.
Périodique
Annals of Diagnostic Pathology
Auteur(s)
Bongiovanni M., Gremaud M., Moulin C.S., Scheidegger C., Biton C., Clément S.
ISSN
1532-8198 (Electronic)
ISSN-L
1092-9134
Statut éditorial
Publié
Date de publication
2009
Volume
13
Numéro
2
Pages
101-105
Langue
anglais
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Résumé
Thyroid lesions composed of large follicles that contain abundant colloid are usually regarded as benign hyperplastic or adenomatous nodules both by fine-needle aspiration cytology and histology. In such cases, the pathologist is less likely to request a complete inclusion of the capsule into paraffin block and to look for vascular and/or capsular invasion, the only criteria that permit the differential diagnosis between a benign nodule and a follicular carcinoma. We report the first case of a follicular thyroid carcinoma composed predominantly (>90%) of macrofollicles with a surface area that was up to 5 times larger than the surface area of normal follicles, as calculated with an image analysis system. Capsular invasion was detected in 2 separate foci. The tumor was classified as a minimally invasive follicular carcinoma, macrofollicular variant. This case is detailed to highlight the potential pitfall that may arise from an incomplete histological analysis of a macrofollicular lesion, with particular attention paid to the differential diagnoses.
Mots-clé
Adenocarcinoma, Follicular/pathology, Adenoma/pathology, Adult, Diagnosis, Differential, Female, Humans, Hyperplasia/pathology, Image Interpretation, Computer-Assisted, Immunohistochemistry, Thyroid Neoplasms/pathology
Pubmed
Web of science
Création de la notice
05/02/2015 12:02
Dernière modification de la notice
03/10/2018 10:26
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