Humoral response to Plasmodium falciparum ring-infected erythrocyte surface antigen in a highly endemic area of Papua New Guinea

Détails

ID Serval
serval:BIB_41E677570FF4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Humoral response to Plasmodium falciparum ring-infected erythrocyte surface antigen in a highly endemic area of Papua New Guinea
Périodique
American Journal of Tropical Medicine and Hygiène
Auteur(s)
al-Yaman  F., Genton  B., Falk  M., Anders  R. F., Lewis  D., Hii  J., Beck  H. P., Alpers  M. P.
ISSN
0002-9637 (Print)
Statut éditorial
Publié
Date de publication
01/1995
Volume
52
Numéro
1
Pages
66-71
Notes
Journal Article
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jan
Résumé
The prevalence and concentration of antibodies to ring-infected erythrocyte surface antigen (RESA) were measured in blood samples collected during a cross-sectional survey conducted in Papua New Guinea. Antibodies were measured by enzyme-linked immunosorbent assay to the recombinant RESA protein in 1,398 subjects and to RESA 8 and RESA 11 synthetic peptides in a subsample of 200 adults. Overall, the seropositivity rate to recombinant RESA was 66% and the geometric mean antibody concentration was 28 micrograms/ml. There was a slow increase in antibody prevalence and concentration with age that continued to occur even after 40 years of age. In children less than 10 years of age, there was a significant positive correlation between both RESA antibody prevalence and concentration and concurrent infection with Plasmodium falciparum. The opposite was true in adults more than 20 years of age, with those having a high antibody concentration to RESA being less likely to be parasitemic at the time of the survey. This observation was consistent with the finding of a weak but significant negative correlation between log antibody concentration and log P. falciparum density, which was mainly found in adults. No consistent correlation was found between humoral immune response to RESA and morbidity indicators.
Mots-clé
Adolescent Adult Age Factors Amino Acid Sequence Animals Antibodies, Protozoan/*blood Antigens, Protozoan/chemistry/*immunology Antigens, Surface/chemistry/*immunology Child Child, Preschool Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Female Humans Infant Infant, Newborn Malaria, Falciparum/*epidemiology/immunology Male Molecular Sequence Data Papua New Guinea/epidemiology Plasmodium falciparum/*immunology Prevalence Protozoan Proteins/chemistry/*immunology Recombinant Proteins/chemistry/immunology Seroepidemiologic Studies
Pubmed
Web of science
Création de la notice
28/01/2008 12:48
Dernière modification de la notice
03/03/2018 16:34
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