Differential expression of triiodothyronine receptors in schwannoma and neurofibroma: role of Schwann cell-axon interaction.

Détails

ID Serval
serval:BIB_41DE9DDD6287
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differential expression of triiodothyronine receptors in schwannoma and neurofibroma: role of Schwann cell-axon interaction.
Périodique
Acta neuropathologica
Auteur(s)
Walter I.B., Deruaz J.P., de Tribolet N.
ISSN
0001-6322
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
90
Numéro
2
Pages
142-149
Langue
anglais
Résumé
Regulation of gene expression in Schwann cells may be determined, at least in part, by the interaction of these cells with axons. Two peripheral nerve tumors, neurofibroma and schwannoma, represent good tools for studying Schwann cell activity in the presence or absence of axon action. In the present work we studied the expression of triiodothyronine receptors (T3R) by Schwann cells in these two tumors and also in adult normal sciatic nerve. Confirming the results of the histological examination, immunostaining of the neurofilaments showed the presence of fascicles or scattered axons in all neurofibroma sections studied. In these neurofibromas, Schwann cells did not express T3R immunoreactivity. Furthermore, in adult normal sciatic nerve, Schwann cells which ensheathed axons were devoid of any T3R expression. In contrast, in schwannoma, the complete absence of axons was demonstrated by the lack of neurofilament immunostaining. Here, Schwann cells deprived of axonal interaction displayed clear T3R immunoreactivity. In schwannoma cell cultures, Schwann cells continued to express T3R, even in cultures treated with medium that had been conditioned with rat sensory neurons. On the basis of these results, we suggest that, beside the possible regulatory mechanisms for T3R, the synthesis of T3R is regulated, at least in part, by Schwann cell-axon interaction.
Mots-clé
Animals, Autopsy, Axons, Biopsy, Blotting, Western, Cells, Cultured, Immunohistochemistry, Neurilemmoma, Neurofibroma, Rats, Rats, Inbred Strains, Receptors, Thyroid Hormone, Schwann Cells, Sciatic Nerve
Pubmed
Web of science
Création de la notice
26/03/2009 12:22
Dernière modification de la notice
03/03/2018 16:34
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