Does uranium induce circulatory diseases? First results from a French cohort of uranium workers

Détails

ID Serval
serval:BIB_41DCA7D1355F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Does uranium induce circulatory diseases? First results from a French cohort of uranium workers
Périodique
Occupational and Environmental Medicine
Auteur(s)
Guseva Canu Irina, Garsi Jérome P., Caër-Lorho Sylvaine, Jacob Sophie, Collomb Philippe, Acker Alain, Laurier Dominique
ISSN
1470-7926 (Electronic)
ISSN-L
1351-0711
Statut éditorial
Publié
Date de publication
06/2012
Peer-reviewed
Oui
Volume
69
Numéro
6
Pages
404-409
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Increased risk of circulatory system diseases (CSDs) was observed in nuclear workers handling uranium and plutonium in Russia and the UK. This work examines the CSD mortality after chronic intake of uranium among 2897 workers (79,892 person-years) at a uranium processing plant (1960-2006) in France.
Cumulative exposure to different uranium compounds, classified by their isotopic composition and solubility type, was quantified on the basis of a plant-specific job-exposure matrix and individual job histories. HRs and associated 95% CI for CSD (n = 111) and specific CSD categories were estimated using Cox regression models, stratified on sex and birth cohort and adjusted for potential confounders. The effect of smoking was analysed among 260 smokers (42 CSD deaths).
Compared to unexposed workers, CSD mortality was increased among workers exposed to slowly soluble reprocessed uranium (RPU) (HR = 2.13, 95% CI = 0.96 to 4.70) and natural uranium (HR = 1.73, 95% CI = 1.11 to 2.69). The risk increased with cumulative exposure and exposure duration. In the subgroup of smokers, the risk estimates were higher but with larger CIs: HR=1.91 (95% CI = 0.92 to 3.98) for natural uranium and HR = 4.78 (95% CI = 1.38 to 16.50) for RPU.
The authors observed that exposure to slowly soluble uranium, namely RPU, may increase the risk of CSD mortality. However, these results are preliminary since the study is lacking statistical power and many other biological and lifestyle-related factors may cause CSD. More detailed investigations are necessary to confirm these findings and analyse in depth the effects of internal radiation exposure on the circulatory system.

Mots-clé
Adult, Cardiovascular Diseases/etiology, Cardiovascular Diseases/mortality, Female, Follow-Up Studies, France, Humans, Male, Middle Aged, Nuclear Power Plants, Occupational Diseases/etiology, Occupational Diseases/mortality, Occupational Exposure/adverse effects, Occupational Exposure/statistics & numerical data, Proportional Hazards Models, Radiation Injuries/etiology, Radiation Injuries/mortality, Risk Factors, Uranium/adverse effects, Uranium Compounds/adverse effects
Pubmed
Web of science
Création de la notice
12/09/2017 14:20
Dernière modification de la notice
03/03/2018 16:34
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