Effect of major hepatectomy on glucose and lactate metabolism.

Détails

ID Serval
serval:BIB_41D9EEDDB95D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of major hepatectomy on glucose and lactate metabolism.
Périodique
Annals of surgery
Auteur(s)
Chioléro R., Tappy L., Gillet M., Revelly J.P., Roth H., Cayeux C., Schneiter P., Leverve X.
ISSN
0003-4932
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
229
Numéro
4
Pages
505-13
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
BACKGROUND: The liver plays an important role in glucose and lactate metabolism. Major hepatectomy may therefore be suspected to cause alterations of glucose and lactate homeostasis. METHODS: Thirteen subjects were studied: six patients after major hepatectomy and seven healthy subjects who had fasted overnight. Glucose turnover was measured with 6,6(2)H glucose. Lactate metabolism was assessed using two complementary approaches: 13C-glucose synthesis and 13CO2 production from an exogenous 13C-labeled lactate load infused over 15 minutes were measured, then the plasma lactate concentrations observed over 185 minutes after lactate load were fitted using a biexponential model to calculate lactate clearance, endogenous production, and half-lives. RESULTS: Three to five liver segments were excised. Compared to healthy controls, the following results were observed in the patients: 1) normal endogenous glucose production; 2) unchanged 13C-lactate oxidation and transformation into glucose; 3) similar basal plasma lactate concentration, lactate clearance, and lactate endogenous production; 4) decreased plasma lactate half-life 1 and increased half-life 2. CONCLUSIONS: Glucose and lactate metabolism are well maintained in patients after major hepatectomy, demonstrating a large liver functional reserve. Reduction in the size of normal liver parenchyma does not lead to hyperlactatemia. The use of a pharmacokinetic model, however, allows the detection of subtle alterations of lactate metabolism.
Mots-clé
Adult, Aged, Female, Glucose, Hepatectomy, Humans, Lactic Acid, Male, Middle Aged
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
03/03/2018 16:34
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