Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.

Détails

ID Serval
serval:BIB_41D9A6840882
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
Périodique
Current Biology
Auteur(s)
Thome M., Hofmann K., Burns K., Martinon F., Bodmer J.L., Mattmann C., Tschopp J.
ISSN
0960-9822[print], 0960-9822[linking]
Statut éditorial
Publié
Date de publication
1998
Volume
8
Numéro
15
Pages
885-888
Langue
anglais
Résumé
Members of the tumor necrosis factor receptor (TNFR) superfamily have an important role in the induction of cellular signals resulting in cell growth, differentiation and death. TNFR-1 recruits and assembles a signaling complex containing a number of death domain (DD)-containing proteins, including the adaptor protein TRADD and the serine/threonine kinase RIP, which mediates TNF-induced NF-kappa B activation. RIP also recruits caspase-2 to the TNFR-1 signaling complex via the adaptor protein RAIDD, which contains a DD and a caspase-recruiting domain (CARD). Here, we have identified a RIP-like kinase, termed CARDIAK (for CARD-containing interleukin (IL)-1 beta converting enzyme (ICE) associated kinase), which contains a serine/threonine kinase domain and a carboxy-terminal CARD. Overexpression of CARDIAK induced the activation of both NF-kappa B and Jun N-terminal kinase (JNK). CARDIAK interacted with the TNFR-associated factors TRAF-1 and TRAF-2, and a dominant-negative form of TRAF-2 inhibited CARDIAK-induced NF-kappa B activation. Interestingly, CARDIAK specifically interacted with the CARD of caspase-1 (previously known as ICE), and this interaction correlated with the processing of pro-caspase-1 and the formation of the active p20 subunit of caspase-1. Together, these data suggest that CARDIAK may be involved in NF-kappa B/JNK signaling and in the generation of the proinflammatory cytokine IL-1 beta through activation of caspase-1.
Mots-clé
Amino Acid Sequence, Base Sequence, Calcium-Calmodulin-Dependent Protein Kinases/metabolism, Caspase 1/metabolism, Cell Line, Transformed, Humans, JNK Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases, Molecular Sequence Data, NF-kappa B/metabolism, Protein Kinases, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/metabolism, Proteins/chemistry, Proteins/metabolism, Receptor-Interacting Protein Serine-Threonine Kinase 2, Receptor-Interacting Protein Serine-Threonine Kinases, Receptors, Tumor Necrosis Factor/metabolism, Sequence Homology, Amino Acid, TNF Receptor-Associated Factor 1, TNF Receptor-Associated Factor 2
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:17
Dernière modification de la notice
08/05/2019 17:41
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