Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism.

Détails

ID Serval
serval:BIB_41D0E57B56E2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism.
Périodique
Scientific reports
Auteur(s)
Jouffe C., Gobet C., Martin E., Métairon S., Morin-Rivron D., Masoodi M., Gachon F.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
21/04/2016
Peer-reviewed
Oui
Volume
6
Pages
24631
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Through evolution, most of the living species have acquired a time keeping system to anticipate daily changes caused by the rotation of the Earth. In all of the systems this pacemaker is based on a molecular transcriptional/translational negative feedback loop able to generate rhythmic gene expression with a period close to 24 hours. Recent evidences suggest that post-transcriptional regulations activated mostly by systemic cues play a fundamental role in the process, fine tuning the time keeping system and linking it to animal physiology. Among these signals, we consider the role of lipid transport and metabolism regulated by SCP2. Mice harboring a deletion of the Scp2 locus present a modulated diurnal accumulation of lipids in the liver and a perturbed activation of several signaling pathways including PPARα, SREBP, LRH-1, TORC1 and its upstream regulators. This defect in signaling pathways activation feedbacks upon the clock by lengthening the circadian period of animals through post-translational regulation of core clock regulators, showing that rhythmic lipid transport is a major player in the establishment of rhythmic mRNA and protein expression landscape.

Mots-clé
Animals, Carrier Proteins/genetics, Carrier Proteins/metabolism, Circadian Clocks, Circadian Rhythm/genetics, Cluster Analysis, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Lipid Metabolism, Male, Metabolic Networks and Pathways, Mice, Mice, Knockout, Protein Processing, Post-Translational, Signal Transduction
Pubmed
Open Access
Oui
Création de la notice
10/05/2016 17:55
Dernière modification de la notice
20/08/2019 13:42
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