Formation of 12-lipoxygenase metabolites in rat cerebral cortical slices: stimulation by calcium ionophore, glutamate and N-methyl-D-aspartate
Details
Serval ID
serval:BIB_41B622FD0F68
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Formation of 12-lipoxygenase metabolites in rat cerebral cortical slices: stimulation by calcium ionophore, glutamate and N-methyl-D-aspartate
Journal
Journal of Neural Transmission. Supplementum
ISSN
0303-6995 (Print)
Publication state
Published
Issued date
1990
Volume
29
Pages
29-37
Notes
In Vitro Journal Article Research Support, Non-U.S. Gov't Review
Abstract
The 12-lipoxygenase pathway of arachidonic acid metabolism in rat cerebral cortex slices is stimulated by exogenous arachidonic acid, Ca2+ ionophore A23187, phorbol ester, glutamate, N-methyl-D-aspartate (NMDA) but not by kainate and other neurotransmitters except norepinephrine. The 12-hydroxyeicosatetraenoic acid formed is the (S)-enantiomer. A specific role for 12-lipoxygenase metabolites in NMDA receptor activation and long term potentiation is proposed.
Keywords
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Arachidonate 12-Lipoxygenase/*metabolism Arachidonate Lipoxygenases/*metabolism Aspartic Acid/*analogs & derivatives/pharmacology Calcimycin/*pharmacology Cerebral Cortex/drug effects/*enzymology Glutamates/*pharmacology Glutamic Acid Hydroxyeicosatetraenoic Acids/metabolism N-Methylaspartate Neurotransmitter Agents/pharmacology Phorbol Esters/*pharmacology
Pubmed
Web of science
Create date
24/01/2008 13:17
Last modification date
20/08/2019 13:42
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