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Formation of 12-lipoxygenase metabolites in rat cerebral cortical slices: stimulation by calcium ionophore, glutamate and N-methyl-D-aspartate
Journal of Neural Transmission. Supplementum
In Vitro Journal Article Research Support, Non-U.S. Gov't Review
The 12-lipoxygenase pathway of arachidonic acid metabolism in rat cerebral cortex slices is stimulated by exogenous arachidonic acid, Ca2+ ionophore A23187, phorbol ester, glutamate, N-methyl-D-aspartate (NMDA) but not by kainate and other neurotransmitters except norepinephrine. The 12-hydroxyeicosatetraenoic acid formed is the (S)-enantiomer. A specific role for 12-lipoxygenase metabolites in NMDA receptor activation and long term potentiation is proposed.
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Arachidonate 12-Lipoxygenase/*metabolism Arachidonate Lipoxygenases/*metabolism Aspartic Acid/*analogs & derivatives/pharmacology Calcimycin/*pharmacology Cerebral Cortex/drug effects/*enzymology Glutamates/*pharmacology Glutamic Acid Hydroxyeicosatetraenoic Acids/metabolism N-Methylaspartate Neurotransmitter Agents/pharmacology Phorbol Esters/*pharmacology
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