Emphysème pulmonaire: mécanismes et nouvelles perspectives thérapeutiques [Pulmonary emphysema: mechanisms and therapeutic perspectives]

Détails

ID Serval
serval:BIB_41AAE5CBFC1C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Emphysème pulmonaire: mécanismes et nouvelles perspectives thérapeutiques [Pulmonary emphysema: mechanisms and therapeutic perspectives]
Périodique
Revue Médicale Suisse
Auteur(s)
Egger B., Aubert J.D.
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2005
Volume
1
Numéro
41
Pages
2665-2672
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review
Résumé
Emphysema is one of the components of chronic obstructive pulmonary disease beside the bronchial, vascular and systemic parts. The pathogenesis involves an inflammatory process (macrophages, neutrophiles and lymphocytes), but also an imbalance between proteases-anti-proteases and the oxidative stress by the formation of oxygen radicals. On the therapeutic level, these physiopathological pathways are the rational basis to the progressive use of antioxidants (mainly N-acetylcysteine) or, for the moment at an experimental level, of anti-proteases (inhibitors of serine proteases, cysteine proteases and the matrix metalloproteases). To reach the secondary lobule, site of the emphysema, the inhaled future treatments will have to be constituted of small particles, as in cigarette smoke, in order to distribute into the most homogeneous way the affected lung.
Mots-clé
Humans, Pulmonary Emphysema
Pubmed
Création de la notice
21/01/2008 13:54
Dernière modification de la notice
03/03/2018 16:34
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