Article: article from journal or magazin.
A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas
Cancer Genetics and Cytogenetics
PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't
Increasing clinical and pathological evidence suggests that malignant fibrous histiocytomas (MFH) comprise a heterogeneous tumor group. In a series of 108 MFH tested by comparative genomic hybridization, we found in 22 tumors high-level coamplification of the 12q14 approximately q15 chromosome region with other loci, a genetics strongly reminiscent of what has been observed for well-differentiated liposarcomas. Nevertheless, these MFH differ from liposarcomas by a high recurrence of coamplified partners because coamplified loci were seen at 1p32 in nine cases, 6q23 in seven cases, and 12q24 in six cases. The same recurrence was observed in a series of dedifferentiated liposarcomas, but not in a series of well-differentiated liposarcomas. These observations demonstrate that a subgroup of MFH share a genetic partner very similar to that observed in liposarcomas, and suggest that the undifferentiated status of these tumors is closely related to the amplifications of specific chromosome loci
Allelic Imbalance/Cell Differentiation/Chromosome Mapping/Chromosomes,Human,Pair 1/Chromosomes,Human,Pair 12/Chromosomes,Human,Pair 6/Histiocytoma,Benign Fibrous/genetics/Pathology/Humans/In Situ Hybridization,Fluorescence/Liposarcoma/Nucleic Acid Hybridization
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