Acid sensing by the Drosophila olfactory system.

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_416B5FB0166D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Acid sensing by the Drosophila olfactory system.
Périodique
Nature
Auteur(s)
Ai M., Min S., Grosjean Y., Leblanc C., Bell R., Benton R., Suh G.S.
ISSN
1476-4687[electronic], 0028-0836[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
468
Numéro
7324
Pages
691-695
Langue
anglais
Résumé
The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating. How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly, Drosophila melanogaster, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors. In vivo calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the IR64a gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery.
Mots-clé
Acetic Acid/analysis, Acetic Acid/pharmacology, Acids/analysis, Acids/pharmacology, Animals, Arthropod Antennae/anatomy & histology, Arthropod Antennae/cytology, Calcium Signaling/drug effects, Carbon Dioxide/metabolism, Carbonic Acid/metabolism, Carbonic Acid/pharmacology, Drosophila Proteins/metabolism, Drosophila melanogaster/anatomy & histology, Drosophila melanogaster/cytology, Maze Learning, Odors/analysis, Olfactory Pathways/cytology, Olfactory Pathways/drug effects, Receptors, Ionotropic Glutamate/metabolism, Receptors, Odorant/metabolism, Sensilla/cytology, Sensory Receptor Cells/drug effects, Sensory Receptor Cells/metabolism, Temperature
Pubmed
Web of science
Création de la notice
08/03/2011 18:35
Dernière modification de la notice
03/03/2018 16:33
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