Hypersensitivity of skin fibroblasts from basal cell nevus syndrome patients to killing by ultraviolet B but not by ultraviolet C radiation

Détails

ID Serval
serval:BIB_416B22374578
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hypersensitivity of skin fibroblasts from basal cell nevus syndrome patients to killing by ultraviolet B but not by ultraviolet C radiation
Périodique
Cancer Research
Auteur(s)
Applegate  L. A., Goldberg  L. H., Ley  R. D., Ananthaswamy  H. N.
ISSN
0008-5472 (Print)
Statut éditorial
Publié
Date de publication
1990
Volume
50
Numéro
3
Pages
637-641
Notes
DA - 19900309
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
SB - IM
Résumé
Basal cell nevus syndrome (BCNS) is an autosomal dominant genetic disorder in which the afflicted individuals are extremely susceptible to sunlight-induced skin cancers, particularly basal cell carcinomas. However, the cellular and molecular basis for BCNS is unknown. To ascertain whether there is any relationship between genetic predisposition to skin cancer and increased sensitivity of somatic cells from BCNS patients to killing by UV radiation, we exposed skin fibroblasts established from unexposed skin biopsies of several BCNS and age- and sex-matched normal individuals to either UV-B (280-320 nm) or UV-C (254 nm) radiation and determined their survival. The results indicated that skin fibroblasts from BCNS patients were hypersensitive to killing by UV-B but not UV-C radiation as compared to skin fibroblasts from normal individuals. DNA repair studies indicated that the increased sensitivity of BCNS skin fibroblasts to killing by UV-B radiation was not due to a defect in the excision repair of pyrimidine dimers. These results indicate that there is an association between hypersensitivity of somatic cells to killing by UV-B radiation and the genetic predisposition to skin cancer in BCNS patients. In addition, these results suggest that DNA lesions (and repair processes) other than the pyrimidine dimer are also involved in the pathogenesis of sunlight-induced skin cancers in BCNS patients. More important, the UV-B sensitivity assay described here may be used as a diagnostic tool to identify presymptomatic individuals with BCNS
Mots-clé
Basal Cell Nevus Syndrome/Biopsy/Carcinoma,Basal Cell/Cell Survival/Cells/Cells,Cultured/Dna/DNA Repair/Fibroblasts/genetics/Humans/immunology/pathology/Pedigree/physiopathology/Pyrimidine Dimers/radiation effects/Skin/Spectrum Analysis/Ultraviolet Rays
Pubmed
Web of science
Création de la notice
18/02/2008 18:33
Dernière modification de la notice
03/03/2018 16:33
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