Simultaneous topography-guided PRK followed by corneal collagen cross-linking for keratoconus.
Details
Serval ID
serval:BIB_4144CE13F230
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Simultaneous topography-guided PRK followed by corneal collagen cross-linking for keratoconus.
Journal
Journal of refractive surgery
ISSN
1081-597X (Print)
ISSN-L
1081-597X
Publication state
Published
Issued date
09/2009
Peer-reviewed
Oui
Volume
25
Number
9
Pages
S807-11
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
To present the results after simultaneous photorefractive keratectomy (PRK) followed by corneal collagen cross-linking (CXL) for progressive keratoconus.
Twelve patients (14 eyes) with progressive keratoconus were prospectively treated with customized topography-guided PRK with the Pulzar Z1 (wavelength 213 nm, CustomVis) immediately followed by corneal collagen CXL with the use of riboflavin and ultraviolet A irradiation.
Mean follow-up was 10.69+/-5.95 months (range: 3 to 16 months). Mean preoperative spherical equivalent refraction (SE) was -3.03+/-3.23 diopters (D) and defocus was 4.67+/-3.29 D; at last follow-up SE and defocus were statistically significantly reduced to -1.29+/-2.05 D and 3.04+/-2.53 D, respectively (P<.01). Preoperative mean (logMAR) uncorrected visual acuity was 0.99+/-0.81 and best spectacle-corrected visual acuity was 0.21+/-0.19, which improved postoperatively to 0.16+/-0.15 and 0.11+/-0.15, respectively. The mean steepest keratometry was reduced from 48.20+/-3.40 D preoperatively to 45.13+/-1.80 D at last follow-up.
Simultaneous PRK followed by CXL seems to be a promising treatment capable of offering functional vision in patients with keratoconus.
Twelve patients (14 eyes) with progressive keratoconus were prospectively treated with customized topography-guided PRK with the Pulzar Z1 (wavelength 213 nm, CustomVis) immediately followed by corneal collagen CXL with the use of riboflavin and ultraviolet A irradiation.
Mean follow-up was 10.69+/-5.95 months (range: 3 to 16 months). Mean preoperative spherical equivalent refraction (SE) was -3.03+/-3.23 diopters (D) and defocus was 4.67+/-3.29 D; at last follow-up SE and defocus were statistically significantly reduced to -1.29+/-2.05 D and 3.04+/-2.53 D, respectively (P<.01). Preoperative mean (logMAR) uncorrected visual acuity was 0.99+/-0.81 and best spectacle-corrected visual acuity was 0.21+/-0.19, which improved postoperatively to 0.16+/-0.15 and 0.11+/-0.15, respectively. The mean steepest keratometry was reduced from 48.20+/-3.40 D preoperatively to 45.13+/-1.80 D at last follow-up.
Simultaneous PRK followed by CXL seems to be a promising treatment capable of offering functional vision in patients with keratoconus.
Keywords
Adult, Collagen/metabolism, Combined Modality Therapy, Cornea/physiopathology, Corneal Stroma/metabolism, Corneal Topography, Humans, Keratoconus/drug therapy, Keratoconus/metabolism, Keratoconus/surgery, Keratoconus/therapy, Lasers, Solid-State/therapeutic use, Photochemotherapy/methods, Photorefractive Keratectomy/methods, Photosensitizing Agents/therapeutic use, Pilot Projects, Prospective Studies, Riboflavin/therapeutic use, Ultraviolet Rays, Visual Acuity/physiology, Young Adult
Pubmed
Web of science
Create date
01/10/2019 15:46
Last modification date
06/10/2019 5:26
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