Immunometabolism in cancer at a glance.

Détails

ID Serval
serval:BIB_4132BB530AE6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immunometabolism in cancer at a glance.
Périodique
Disease models & mechanisms
Auteur(s)
Singer K., Cheng W.C., Kreutz M., Ho P.C., Siska P.J.
ISSN
1754-8411 (Electronic)
ISSN-L
1754-8403
Statut éditorial
Publié
Date de publication
02/08/2018
Peer-reviewed
Oui
Volume
11
Numéro
8
Pages
-
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Résumé
The scientific knowledge about tumor metabolism has grown at a fascinating rate in recent decades. We now know that tumors are highly active both in their metabolism of available nutrients and in the secretion of metabolic by-products. However, cancer cells can modulate metabolic pathways and thus adapt to specific nutrients. Unlike tumor cells, immune cells are not subject to a 'micro-evolution' that would allow them to adapt to progressing tumors that continuously develop new mechanisms of immune escape. Consequently, immune cells are often irreversibly affected and may allow or even support cancer progression. The mechanisms of how tumors change immune cell function are not sufficiently explored. It is, however, clear that commonly shared features of tumor metabolism, such as local nutrient depletion or production of metabolic 'waste' can broadly affect immune cells and contribute to immune evasion. Moreover, immune cells utilize different metabolic programs based on their subtype and function, and these immunometabolic pathways can be modified in the tumor microenvironment. In this review and accompanying poster, we identify and describe the common mechanisms by which tumors metabolically affect the tumor-infiltrating cells of native and adaptive immunity, and discuss how these mechanisms may lead to novel therapeutic opportunities.
Mots-clé
Animals, Humans, Immunity, Lymphocytes/metabolism, Neoplasms/immunology, Neoplasms/metabolism, Salts/metabolism, Tumor Microenvironment/immunology, Cancer, Metabolism, Metabolites, Nutrients, T cells, Tumor immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/08/2018 15:35
Dernière modification de la notice
08/05/2019 17:39
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