Organ-specific lymphatic vasculature: From development to pathophysiology.

Détails

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Etat: Serval
Version: Final published version
Licence: CC BY-NC-SA 4.0
ID Serval
serval:BIB_41205D392493
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Organ-specific lymphatic vasculature: From development to pathophysiology.
Périodique
The Journal of experimental medicine
Auteur(s)
Petrova T.V., Koh G.Y.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
02/01/2018
Peer-reviewed
Oui
Volume
215
Numéro
1
Pages
35-49
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and pathophysiological processes. Lymphatic vessels show remarkable plasticity and heterogeneity, reflecting their functional specialization to control the tissue microenvironment. Moreover, alternative developmental origins of lymphatic endothelial cells in some organs may contribute to the diversity of their functions in adult tissues. This review aims to summarize the most recent findings of organotypic differentiation of lymphatic endothelial cells in terms of their distinct (patho)physiological functions in skin, lymph nodes, small intestine, brain, and eye. We discuss recent advances in our understanding of the heterogeneity of lymphatic vessels with respect to the organ-specific functional and molecular specialization of lymphatic endothelium, such as the hybrid blood-lymphatic identity of Schlemm's canal, functions of intestinal lymphatics in dietary fat uptake, and discovery of meningeal lymphatic vasculature and perivascular brain lymphatic endothelial cells.
Mots-clé
Animals, Endothelial Cells/metabolism, Humans, Lymphangiogenesis, Lymphatic Vessels/physiology, Lymphatic Vessels/physiopathology, Organ Specificity, Signal Transduction, Tissue Engineering
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/01/2018 19:52
Dernière modification de la notice
29/05/2019 7:08
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