Phenotypic identification of memory cytolytic T lymphocytes in a subset of Lyt-2+ cells

Détails

ID Serval
serval:BIB_4103BA615FFC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Phenotypic identification of memory cytolytic T lymphocytes in a subset of Lyt-2+ cells
Périodique
Journal of Immunology
Auteur(s)
Budd  R. C., Cerottini  J. C., MacDonald  H. R.
ISSN
0022-1767 (Print)
Statut éditorial
Publié
Date de publication
02/1987
Volume
138
Numéro
4
Pages
1009-13
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb 15
Résumé
Murine peripheral Lyt-2+ T cells could be subdivided according to surface expression of the Pgp-1 glycoprotein into major (71%) Pgp-1- and minor (29%) Pgp-1+ subsets. A striking correlation was observed between Pgp-1 expression and enrichment for antigen-specific memory cytolytic T lymphocyte precursors (CTLp). After immunization with the male minor transplantation antigen H-Y, virtually all the H-Y-specific CTLp were found in the minor Pgp-1+ subset of Lyt-2+ cells. In addition, after alloimmunization the frequency of allospecific CTLp resistant to inhibition by anti-Lyt-2 antibody was markedly enriched within the Pgp-1+ cells, suggesting an enrichment for CTLp bearing high avidity antigen receptors. Taken together, these data suggest that surface Pgp-1 expression is stably acquired at the time of primary antigenic stimulation by virgin T cells. As such, Pgp-1 represents an important marker for identifying a subset of Lyt-2+ T cells with the quantitative and qualitative properties of memory CTLp.
Mots-clé
Animals Antigens, Differentiation, T-Lymphocyte Antigens, Ly/analysis Antigens, Surface/*analysis Female H-Y Antigen/immunology Immunization *Immunologic Memory Male Mice Mice, Inbred C57BL/immunology Mice, Inbred DBA/immunology Phenotype Receptors, Antigen, T-Cell/immunology Receptors, Lymphocyte Homing T-Lymphocytes, Cytotoxic/*classification/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:14
Dernière modification de la notice
03/03/2018 16:30
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