Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients.

Détails

ID Serval
serval:BIB_40ECF91A444C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients.
Périodique
Human Pathology
Auteur(s)
Geyer J.T., Subramaniyam S., Jiang Y., Elemento O., Ferry J.A., de Leval L., Nakashima M.O., Liu Y.C., Martin P., Mathew S., Orazi A., Tam W.
ISSN
1532-8392 (Electronic)
ISSN-L
0046-8177
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
46
Numéro
2
Pages
260-271
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Approximately 30% of patients with follicular lymphoma (FL) transform to a more aggressive malignancy, most commonly diffuse large B cell lymphoma. Rarely, FL transformation results in clinical findings, histology, and immunophenotype reminiscent of B-lymphoblastic leukemia/lymphoma. We report the largest series to date with detailed analysis of 7 such patients. Lymphoblastic transformation occurred on average 2 years after initial diagnosis of FL. Five patients had prior intensive chemotherapy. Two patients developed mature high-grade lymphoma, followed by the lymphoblastic transformation. FL had BCL2 gene rearrangement in 4 of 5 cases. High-grade transformation was accompanied by MYC gene rearrangement (5 of 5). Transformation was characterized by expression of TdT, loss of Bcl6, variable loss of immunoglobulin light chain, and persistence of Pax-5, Bcl2, and CD10. Whole-exome sequencing in 1 case revealed presence of several actionable mutations (CD79B, CCND3, CDK12). FL, aggressive mature B cell lymphoma, and lymphoblastic transformation were clonally related in 6 evaluable cases. After transformation, survival ranged from 1 to 14 months. Four patients died of disease, 2 were in remission after stem cell transplant, and 1 was alive with disease.
Pubmed
Web of science
Création de la notice
05/01/2015 10:14
Dernière modification de la notice
03/03/2018 16:30
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