Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea

Détails

ID Serval
serval:BIB_40D92F3CD64F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea
Périodique
American Journal of Tropical Medicine and Hygiène
Auteur(s)
Casey  G. J., Ginny  M., Uranoli  M., Mueller  I., Reeder  J. C., Genton  B., Cowman  A. F.
ISSN
0002-9637 (Print)
Statut éditorial
Publié
Date de publication
03/2004
Volume
70
Numéro
3
Pages
251-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
A study was conducted in Papua New Guinea to analyze Plasmodium falciparum drug resistance polymorphisms in patients presenting with resistant malaria. One hundred ninety-nine P. falciparum-positive patients were recruited at two sites, Madang and Maprik. Exposure to the 4-aminoquinolines chloroquine and amodiaquine was uniformly high, at 84% overall. However, 59% of these were taken in various combinations of sulfadoxine/pyrimethamine and/or primaquine and/or quinine. Two markers for 4-aminoquinoline resistance, P. falciparum chloroquine resistance transporter 76T and P. falciparum multidrug resistance 1, were fixed in the population and two markers for pyrimethamine resistance, dihydrofolate reductase (dhps) 59R and 108N, were found at moderate to high levels, overall 60% and 75%, respectively. No polymorphisms in dhps associated with sulfadoxine resistance were present. Differences between the two sites are analyzed. The study period encompasses a change in standard malaria treatment policy. These findings stress the need for regular monitoring of the effects of standard drug treatment of uncomplicated malaria in Papua New Guinea.
Mots-clé
Aminoquinolines/therapeutic use Amodiaquine/therapeutic use Animals Chloroquine/therapeutic use Drug Resistance/genetics Humans Malaria, Falciparum/*drug therapy Membrane Proteins/genetics P-Glycoprotein/genetics Papua New Guinea Plasmodium falciparum/drug effects/*genetics Polymorphism, Genetic Protozoan Proteins Treatment Failure
Pubmed
Web of science
Création de la notice
28/01/2008 12:48
Dernière modification de la notice
03/03/2018 16:29
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