Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men

Détails

ID Serval
serval:BIB_40C8D07C755A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men
Périodique
Annals of Oncology
Auteur(s)
Galeone  Carlotta, Pelucchi  Claudio, Levi  Fabio, Negri  Eva, Talamini  Renato, Franceschi  Silvia, La Vecchia  Carlo
ISSN
0923-7534
Statut éditorial
Publié
Date de publication
2006
Volume
17
Numéro
3
Pages
521-525
Notes
SAPHIRID:50200
Résumé
BACKGROUND: Dietary folate has been inversely related to the risk of several cancers. However, studies on the role of dietary folate in oesophageal cancer are scanty. PATIENTS AND METHODS: Using data from a multicentric case-control study conducted in Italy and Switzerland between 1992 and 1999, we investigated the association between dietary folate intake and oesophageal squamous-cell carcinoma (OSCC) among 351 men with incident, histologically confirmed OSCC and 875 hospital controls admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Intake of folate and other nutrients was computed from a validated food frequency questionnaire. RESULTS: The multivariate odds ratios (ORs) of OSCC were 0.68 (95% confidence intervals, CI: 0.46-1.00) for the highest versus the lowest tertile of folate intake, and 0.84 (95% CI: 0.72-0.99) for an increment of folate intake equal to a standard deviation (98 microg/day). The inverse relation was somewhat stronger in strata of high methionine, vitamin B6 and alcohol intake, and did not vary substantially according to age and smoking habits. CONCLUSION: Dietary folate was inversely related to OSCC risk in this population with high alcohol consumption and infrequent use of supplements and multivitamins. [Authors]
Mots-clé
Carcinoma, Squamous Cell , Esophageal Neoplasms , Folic Acid , Men
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/03/2008 15:58
Dernière modification de la notice
08/05/2019 17:38
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