Editing through multiple bonds: threonine detection.

Détails

ID Serval
serval:BIB_40953A0A2136
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Editing through multiple bonds: threonine detection.
Périodique
Magnetic Resonance in Medicine
Auteur(s)
Marjanska M., Henry P.G., Uğurbil K., Gruetter R.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
2008
Volume
59
Numéro
2
Pages
245-251
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Résumé
In in vivo (1)H spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of either threonine or lactate without and even with editing technically challenging. In this study, the threonine signal was detected using a single-shot multiple-bond editing technique and quantified in vivo in both rat and human brains. A threonine concentration was estimated at 0.8 +/- 0.3 mM (mean +/- SD, n = 6) in the rat brain and at approximately 0.33 mM in the human brain.
Mots-clé
Animals, Brain/metabolism, Humans, Hydrogen-Ion Concentration, Lactates/metabolism, Magnetic Resonance Spectroscopy/methods, Male, Phantoms, Imaging, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Threonine/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
08/05/2019 17:37
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