Roles of Peroxisome Proliferator-Activated Receptor β/δ in skeletal muscle physiology.

Détails

ID Serval
serval:BIB_4088E5846B49
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Roles of Peroxisome Proliferator-Activated Receptor β/δ in skeletal muscle physiology.
Périodique
Biochimie
Auteur(s)
Manickam R., Wahli W.
ISSN
1638-6183 (Electronic)
ISSN-L
0300-9084
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
136
Pages
42-48
Langue
anglais
Résumé
More than two decades of studying Peroxisome Proliferator-Activated Receptors (PPARs) has led to an understanding of their implications in various physiological processes that are key for health and disease. All three PPAR isotypes, PPARα, PPARβ/δ, and PPARγ, are activated by a variety of molecules, including fatty acids, eicosanoids and phospholipids, and regulate a spectrum of genes involved in development, lipid and carbohydrate metabolism, inflammation, and proliferation and differentiation of many cell types in different tissues. The hypolipidemic and antidiabetic functions of PPARα and PPARγ in response to fibrate and thiazolidinedione treatment, respectively, are well documented. However, until more recently the functions of PPARβ/δ were less well defined, but are now becoming more recognized in fatty acid metabolism, energy expenditure, and tissue repair. Skeletal muscle is an active metabolic organ with high plasticity for adaptive responses to varying conditions such as fasting or physical exercise. It is the major site of energy expenditure resulting from lipid and glucose catabolism. Here, we review the multifaceted roles of PPARβ/δ in skeletal muscle physiology.

Pubmed
Web of science
Création de la notice
12/01/2017 16:35
Dernière modification de la notice
03/03/2018 16:29
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