Embryonic and fetal development: fundamental research.

Détails

ID Serval
serval:BIB_4083A37C9A2C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Embryonic and fetal development: fundamental research.
Périodique
Reproductive Toxicology
Auteur(s)
Schmid B.P., Honegger P., Kucera P.
ISSN
0890-6238 (Print)
ISSN-L
0890-6238
Statut éditorial
Publié
Date de publication
1993
Volume
7 Suppl 1
Pages
155-164
Langue
anglais
Résumé
Much progress has been made over the past decades in the development of in vitro techniques for the assessment of chemically induced effects in embryonic and fetal development. In vitro assays have originally been developed to provide information on the mechanism of action of normal development, and have hence more adequately been used in fundamental research. These assays had to undergo extensive modification to be used in developmental toxicity testing. The present paper focuses on the rat whole embryo culture system, but also reviews modifications that were undertaken for the in vitro chick embryo system and the aggregate cultures of fetal rat brain cells. Today these tests cannot replace the existing in vivo developmental toxicity tests. They can, however, be used to screen chemicals for further development or further testing. In addition, these in vitro tests provide valuable information on the mechanisms of developmental toxicity and help to understand the relevancy of findings for humans. In vitro systems, combined with selected in vivo testing and pharmacokinetic investigations in animals and humans, can thus provide essential information for human risk assessment.
Mots-clé
Animals, Cells, Cultured, Chick Embryo, Drug Evaluation, Preclinical/methods, Embryonic and Fetal Development/drug effects, Embryonic and Fetal Development/physiology, Humans, Male, Rats, Research, Toxicology/methods
Pubmed
Web of science
Création de la notice
24/01/2008 14:12
Dernière modification de la notice
03/03/2018 16:29
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