Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.

Détails

ID Serval
serval:BIB_406D727FDB0A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.
Périodique
Human Pathology
Auteur(s)
Bisig B., Copie-Bergman C., Baia M., Gaulard P., Delbecque K., Fassotte M.F., Boniver J., de Leval L.
ISSN
1532-8392[electronic], 0046-8177[linking]
Statut éditorial
Publié
Date de publication
2009
Volume
40
Numéro
10
Pages
1504-1509
Langue
anglais
Résumé
The genetic alterations underlying extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type are heterogeneous and show variation according to the tumor site. Here, we report a case of mucosa-associated lymphoid tissue lymphoma of the gallbladder with genetic characterization. This lymphoma, diagnosed in a 75-year-old woman who underwent cholecystectomy for suspected acute cholecystitis, presented as diffuse thickening of the gallbladder wall. The morphology was typical of mucosa-associated lymphoid tissue lymphoma, and by immunophenotype, the tumor cells were CD20+ CD5- CD10- CD23- CD43- BCL6- BCL2+ IgM+ IgD- lambda+, with moderate nuclear expression of BCL10. Interphase fluorescence in situ hybridization analysis on paraffin sections, using a fusion probe for API2/MALT1, demonstrated 2 fusion signals in most nuclei, bringing the first documentation of a t(11;18)(q21;q21) in this exceptional primary disease location.
Mots-clé
Aged, Cholecystectomy, Female, Gallbladder Neoplasms/genetics, Gallbladder Neoplasms/immunology, Humans, Immunohistochemistry, Immunophenotyping, In Situ Hybridization, Fluorescence, Lymphoma, B-Cell, Marginal Zone/genetics, Lymphoma, B-Cell, Marginal Zone/immunology, Oncogene Proteins, Fusion/genetics
Pubmed
Création de la notice
22/10/2010 14:53
Dernière modification de la notice
03/03/2018 16:28
Données d'usage