Activation of metabotropic glutamate 5 and NMDA receptors underlies the induction of persistent bursting and associated long-lasting changes in CA3 recurrent connections

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_406A5435002A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Activation of metabotropic glutamate 5 and NMDA receptors underlies the induction of persistent bursting and associated long-lasting changes in CA3 recurrent connections
Périodique
Journal of Neuroscience
Auteur(s)
Stoop Ron, Conquet François, Zuber Benoit, Voronin Léon L., Pralong Etienne
ISSN
0270-6474
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
23
Numéro
13
Pages
5634-5644
Langue
anglais
Notes
SAPHIRID:67368
Résumé
The aim of this study was to describe the induction and expression mechanisms of a persistent bursting activity in a horizontal slice preparation of the rat limbic system that includes the ventral part of the hippocampus and the entorhinal cortex. Disinhibition of this preparation by bicuculline led to interictal-like bursts in the CA3 region that triggered synchronous activity in the entorhinal cortex. Washout of bicuculline after a 1 hr application resulted in a maintained production of hippocampal bursts that continued to spread to the entorhinal cortex. Separation of CA3 from the entorhinal cortex caused the activity in the latter to become asynchronous with CA3 activity in the presence of bicuculline and disappear after washout; however, in CA3, neither the induction of bursting nor its persistence were affected. Associated with the CA3 persistent bursting, a strengthening of recurrent collateral excitatory input to CA3 pyramidal cells and a decreased input to CA3 interneurons was found. Both the induction of the persistent bursting and the changes in synaptic strength were prevented by antagonists of metabotropic glutamate 5 (mGlu5) or NMDA receptors or protein synthesis inhibitors and did not occur in slices from mGlu5 receptor knock-out mice. The above findings suggest potential synaptic mechanisms by which the hippocampus switches to a persistent interictal bursting mode that may support a spread of interictal-like bursting to surrounding temporal lobe regions.
Pubmed
Web of science
Création de la notice
11/03/2008 10:57
Dernière modification de la notice
20/08/2019 13:38
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