Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_4020D8E97210
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept.
Journal
iScience
Author(s)
Uslu E., Rana V.K., Anagnostopoulos S., Karami P., Bergadano A., Courbon C., Gorostidi F., Sandu K., Stergiopulos N., Pioletti D.P.
ISSN
2589-0042 (Electronic)
ISSN-L
2589-0042
Publication state
Published
Issued date
21/07/2023
Peer-reviewed
Oui
Volume
26
Number
7
Pages
107168
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Tracheomalacia (TM) is a condition characterized by a weak tracheal cartilage and/or muscle, resulting in excessive collapse of the airway in the newborns. Current treatments including tracheal reconstruction, tracheoplasty, endo- and extra-luminal stents have limitations. To address these limitations, this work proposes a new strategy by wrapping an adhesive hydrogel patch around a malacic trachea. Through a numerical model, first it was demonstrated that a hydrogel patch with sufficient mechanical and adhesion strength can preserve the trachea's physiological shape. Accordingly, a new hydrogel providing robust adhesion on wet tracheal surfaces was synthesized employing the hydroxyethyl acrylamide (HEAam) and polyethylene glycol methacrylate (PEGDMA) as main polymer network and crosslinker, respectively. Ex vivo experiments revealed that the adhesive hydrogel patches can restrain the collapsing of malacic trachea under negative pressure. This study may open the possibility of using an adhesive hydrogel as a new approach in the difficult clinical situation of tracheomalacia.
Keywords
Applied sciences, Biomaterials
Pubmed
Web of science
Open Access
Yes
Create date
19/07/2023 14:48
Last modification date
25/01/2024 8:34
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