The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance

Details

Serval ID
serval:BIB_3FF491C6CDD1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance
Journal
FEBS Letters
Author(s)
Hofmann  K., Tschopp  J.
ISSN
0014-5793 (Print)
Publication state
Published
Issued date
09/1995
Volume
371
Number
3
Pages
321-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep 11
Abstract
The interaction of Fas (Apo-1) and TNF receptor-1 with their respective ligands can lead to cell death. The so-called death domain, a sequence motif present in the cytoplasmic portion of the two receptors, has been identified as a critical structural element involved in signal transduction that leads to apoptosis. Here we describe several additional proteins which contain a death domain. Novel members of this family include proteins known to be implicated not only in apoptosis but also in neuron guidance.
Keywords
Amino Acid Sequence Animals Antigens, CD95/*metabolism *Apoptosis *Axons Base Sequence Binding Sites Cell Movement Databases, Factual Humans Molecular Sequence Data Receptors, Tumor Necrosis Factor/*metabolism
Pubmed
Web of science
Create date
24/01/2008 16:18
Last modification date
20/08/2019 14:37
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