Article: article from journal or magazin.
L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells.
T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin-negative CCR7- effector and memory CD8+ T cells. This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable interactions with and killed antigen-bearing dendritic cells, limiting the ability of these dendritic cells to activate naive CD4+ and CD8+ T cells. The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses.
Amino Acid Sequence, Animals, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Cell Movement/immunology, Cells, Cultured, Cytotoxicity, Immunologic, Dendritic Cells/immunology, Dendritic Cells/pathology, Immunologic Memory, L-Selectin/biosynthesis, L-Selectin/metabolism, Lymph Nodes/immunology, Lymph Nodes/pathology, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Receptors, CCR7, Receptors, Chemokine/biosynthesis, Receptors, Chemokine/metabolism, T-Lymphocyte Subsets/immunology
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