Serum TNF in patients with severe malaria treated by exchange transfusion

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Serval ID
serval:BIB_3FE7B54FBE33
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Production externe
Title
Serum TNF in patients with severe malaria treated by exchange transfusion
Journal
Tropical Medicine and Parasitology
Author(s)
Loutan  L., Plancherel  C., Soulier-Lauper  M., Pascual  M., Subilia  L., Chevrolet  J. C., Unger  P. F., Grau  G. E.
ISSN
0177-2392
Publication state
Published
Issued date
12/1992
Volume
43
Number
4
Pages
285-6
Notes
Case Reports
Journal Article --- Old month value: Dec
Abstract
The authors report on three cases of severe P. falciparum malaria successfully treated by iv quinine and exchange transfusion. Serum concentrations of Tumor Necrosis Factor (TNF) were determined before and during treatment. After an initial decrease, serum levels of TNF remained markedly elevated during the first 48 hours despite exchange transfusion. Though exchange transfusion accelerates the elimination of parasites from the blood, it seems to have no immediate effects on reducing serum levels of cytokines such as TNF.
Keywords
Adult Chemotherapy, Adjuvant *Exchange Transfusion, Whole Blood Humans Infusions, Intravenous Malaria, Falciparum/*blood/drug therapy/therapy Male Middle Aged Quinine/administration & dosage/*therapeutic use Tumor Necrosis Factor-alpha/*analysis
Pubmed
1293736
Web of science
A1992KG55300018
Create date
29/01/2008 14:52
Last modification date
20/08/2019 14:37
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