Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications.

Détails

ID Serval
serval:BIB_3FDCE081E560
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications.
Périodique
Analytical and Bioanalytical Chemistry
Auteur(s)
Déglon J., Thomas A., Mangin P., Staub C.
ISSN
1618-2642
1618-2650 (Electronic)
Statut éditorial
Publié
Date de publication
2012
Volume
402
Numéro
8
Pages
2485-2498
Langue
anglais
Résumé
Because of the emergence of dried blood spots (DBS) as an attractive alternative to conventional venous plasma sampling in many pharmaceutical companies and clinical laboratories, different analytical approaches have been developed to enable automated handling of DBS samples without any pretreatment. Associated with selective and sensitive MS-MS detection, these procedures give good results in the rapid identification and quantification of drugs (generally less than 3 min total run time), which is desirable because of the high throughput requirements of analytical laboratories. The objective of this review is to describe the analytical concepts of current direct DBS techniques and to present their advantages and disadvantages, with particular focus on automation capacity and commercial availability. Finally, an overview of the different biomedical applications in which these concepts could be of major interest will be presented.
Pubmed
Web of science
Création de la notice
12/03/2012 17:18
Dernière modification de la notice
03/03/2018 16:26
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