N-of-1 trials ou essais thérapeutiques individuels : un test probant pour diagnostiquer l’efficacité thérapeutique [N-of-1 trials or single-patient therapeutic tests: evidence-based tests to diagnose therapeutic efficacy]

Details

Serval ID
serval:BIB_3FBD585C601E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
N-of-1 trials ou essais thérapeutiques individuels : un test probant pour diagnostiquer l’efficacité thérapeutique [N-of-1 trials or single-patient therapeutic tests: evidence-based tests to diagnose therapeutic efficacy]
Journal
Revue medicale suisse
Author(s)
Diezi L., Buclin T.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
06/11/2019
Peer-reviewed
Oui
Volume
15
Number
670
Pages
2058-2061
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
N-of-1 trials therapeutic tests allow an objective evaluation of treatment efficacy in a single patient. Thereby, they can support off-label prescriptions, or promote treatment safety and efficiency in chronic patients through the deprescription of useless drugs. They also encourage active participation of patients in their medical care. Practically a treatment is compared to a placebo in double blind during a series of randomly alternating periods. Statistical analysis comparing measurements performed in the patient throughout the test enable to evaluate objectively treatment efficacy. The performance of this type of test is now offered to patients and practitioners by the Service of Clinical Pharmacology in the University Hospital of Lausanne.
Keywords
Clinical Trials as Topic/methods, Double-Blind Method, Evidence-Based Practice/methods, Humans, Off-Label Use, Switzerland, Treatment Outcome
Pubmed
Create date
07/11/2019 22:11
Last modification date
22/07/2020 5:26
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