Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones

Détails

ID Serval
serval:BIB_3F908118C242
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones
Périodique
Neuroreport
Auteur(s)
Zurn  A. D., Baetge  E. E., Hammang  J. P., Tan  S. A., Aebischer  P.
ISSN
0959-4965 (Print)
Statut éditorial
Publié
Date de publication
12/1994
Volume
6
Numéro
1
Pages
113-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 30
Résumé
Glial cell line-derived neurotrophic factor (GDNF) has been postulated to be a specific dopaminergic neurotrophic factor since it selectively enhances the survival of dopaminergic neurones in vitro. We report here that GDNF can also act as a neurotrophic factor for motoneurones. GDNF released by GDNF-transfected BHK cells increases the activity of choline acetyltransferase (ChAT) in cultures from embryonic rat ventral mesencephalon containing cholinergic neurones from cranial motor nuclei and in cultured spinal motoneurones. Furthermore, local application of polymer-encapsulated BHK cells releasing GDNF to transected facial nerve in newborn rats diminishes the death of motoneurones normally occurring after axotomy in the neonatal period. The present results indicate that GDNF may have a therapeutic potential in human motoneurone diseases such as amyotrophic lateral sclerosis.
Mots-clé
Animals Base Sequence Brain-Derived Neurotrophic Factor Cells, Cultured Choline O-Acetyltransferase/metabolism Ciliary Neurotrophic Factor Drug Synergism Glial Cell Line-Derived Neurotrophic Factor Mesencephalon/cytology/enzymology Molecular Sequence Data Motor Neurons/*drug effects Nerve Growth Factors/*pharmacology Nerve Tissue Proteins/genetics/*pharmacology Parasympathetic Nervous System/cytology Rats Spinal Cord/cytology
Pubmed
Web of science
Création de la notice
28/01/2008 9:44
Dernière modification de la notice
03/03/2018 16:25
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