Two cases of Takayasu's arteritis occurring under anti-TNF therapy.

Détails

ID Serval
serval:BIB_3F716B1CF304
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Two cases of Takayasu's arteritis occurring under anti-TNF therapy.
Périodique
Joint, Bone, Spine
Auteur(s)
Mariani N., So A., Aubry-Rozier B.
ISSN
1778-7254 (Electronic)
ISSN-L
1297-319X
Statut éditorial
Publié
Date de publication
2013
Volume
80
Numéro
2
Pages
211-213
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish. PDF type: case report
Résumé
Takayasu's arteritis is a granulomatous, large vessel vasculitis that affects the aorta, its major branches and the pulmonary arteries. Compelling evidence exists to support the notion that Takayasu's arteritis is a T-cell mediated process and that tumor necrosis factor alpha (TNFa) is an important factor in the pathogenesis of this disease. Moreover, encouraging results from recent studies support the use of anti-TNFa therapy for relapsing or resistant cases of Takayasu's arteritis. Here, however, we describe the case of two patients: one with seropositive rheumatoid arthritis, the other with HLA-B27 negative spondylarthropathy, who developed Takayasu's arteritis during treatment with TNFa inhibitors (adalimumab and golimumab respectively). This is the first report of Takayasu's arteritis in rheumatic patients under TNFa blocking agents which suggests the presence of different pathogenetic mechanism in a subgroup of patients with Takayasu's arteritis, as well as a potential role of TNFa blockers as triggers of this disease in some cases.
Pubmed
Web of science
Création de la notice
09/01/2013 15:15
Dernière modification de la notice
03/03/2018 16:25
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