The role of circadian timing system on drug metabolism and detoxification.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_3F6A64FF9D4D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The role of circadian timing system on drug metabolism and detoxification.
Périodique
Expert Opinion on Drug Metabolism and Toxicology
Auteur(s)
Gachon F., Firsov D.
ISSN
1744-7607[electronic], 1742-5255[linking]
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
7
Numéro
2
Pages
147-158
Langue
anglais
Résumé
INTRODUCTION: It has been known for a long time that the efficiency and toxicity of drugs change during a 24-h period. However, the molecular mechanisms involved in these processes have started to emerge only recently. AREAS COVERED: This review aims to highlight recent discoveries showing the direct role of the molecular circadian clock in xenobiotic metabolism at the transcriptional and post-transcriptional levels in the liver and intestine, and the different ways of elimination of these metabolized drugs via biliary and urine excretions. Most of the related literature focuses on transcriptional regulation by the circadian clock of xenobiotic metabolism in the liver; however, the role of this timing system in the excretion of metabolized drugs and the importance of the kidney in this phenomenon are generally neglected. The goal of this review is to describe the molecular mechanisms involved in rhythmic drug metabolism and excretion. EXPERT OPINION: Chronopharmacology is used to analyze the metabolism of drugs in mammals according to the time of day. The circadian timing system plays a key role in the changes of toxicity of drugs by influencing their metabolisms in the liver and intestine in addition to their excretion via bile flow and urine.
Mots-clé
chronopharmacology, circadian clock, drug elimination, drug metabolism, liver detoxification, xenobiotic receptors
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/01/2011 18:13
Dernière modification de la notice
08/05/2019 17:33
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