Angiogenesis inhibition for the improvement of photodynamic therapy: The revival of a promising idea.

Details

Serval ID
serval:BIB_3F66C008B9E0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Angiogenesis inhibition for the improvement of photodynamic therapy: The revival of a promising idea.
Journal
Biochimica et Biophysica Acta
Author(s)
Weiss A., Van den Bergh H., Griffioen A.W., Nowak-Sliwinska P.
ISSN
0304-419X
ISSN-L
0304-419X
Publication state
Published
Issued date
2012
Volume
1826
Number
1
Pages
53-70
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Photodynamic therapy (PDT) is a minimally invasive form of treatment, which is clinically approved for the treatment of angiogenic disorders, including certain forms of cancer and neovascular eye diseases. Although the concept of PDT has existed for a long time now, it has never made a solid entrance into the clinical management of cancer. This is likely due to secondary tissue reactions, such as inflammation and neoangiogenesis. The recent development of clinically effective angiogenesis inhibitors has lead to the initiation of research on the combination of PDT with such angiostatic targeted therapies. Preclinical studies in this research field have shown promising results, causing a revival in the field of PDT. This review reports on the current research efforts on PDT and vascular targeted combination therapies. Different combination strategies with angiogenesis inhibition and vascular targeting approaches are discussed. In addition, the concept of increasing PDT selectivity by targeted delivery of photosensitizers is presented. Furthermore, the current insights on sequencing the therapy arms of such combinations will be discussed in light of vascular normalization induced by angiogenesis inhibition.
Pubmed
Web of science
Create date
22/07/2012 20:47
Last modification date
20/08/2019 13:36
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