Angiogenesis inhibition for the improvement of photodynamic therapy: The revival of a promising idea.

Détails

ID Serval
serval:BIB_3F66C008B9E0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Angiogenesis inhibition for the improvement of photodynamic therapy: The revival of a promising idea.
Périodique
Biochimica et Biophysica Acta
Auteur(s)
Weiss A., Van den Bergh H., Griffioen A.W., Nowak-Sliwinska P.
ISSN
0304-419X
ISSN-L
0304-419X
Statut éditorial
Publié
Date de publication
2012
Volume
1826
Numéro
1
Pages
53-70
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Photodynamic therapy (PDT) is a minimally invasive form of treatment, which is clinically approved for the treatment of angiogenic disorders, including certain forms of cancer and neovascular eye diseases. Although the concept of PDT has existed for a long time now, it has never made a solid entrance into the clinical management of cancer. This is likely due to secondary tissue reactions, such as inflammation and neoangiogenesis. The recent development of clinically effective angiogenesis inhibitors has lead to the initiation of research on the combination of PDT with such angiostatic targeted therapies. Preclinical studies in this research field have shown promising results, causing a revival in the field of PDT. This review reports on the current research efforts on PDT and vascular targeted combination therapies. Different combination strategies with angiogenesis inhibition and vascular targeting approaches are discussed. In addition, the concept of increasing PDT selectivity by targeted delivery of photosensitizers is presented. Furthermore, the current insights on sequencing the therapy arms of such combinations will be discussed in light of vascular normalization induced by angiogenesis inhibition.
Pubmed
Web of science
Création de la notice
22/07/2012 21:47
Dernière modification de la notice
03/03/2018 16:25
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