Active suppression of major histocompatibility complex class II gene expression during differentiation from B cells to plasma cells.

Détails

ID Serval
serval:BIB_3F655F1B83E9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Active suppression of major histocompatibility complex class II gene expression during differentiation from B cells to plasma cells.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Latron F., Jotterand-Bellomo M., Maffei A., Scarpellino L., Bernard M., Strominger J.L., Accolla R.S.
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
1988
Volume
85
Numéro
7
Pages
2229-33
Langue
anglais
Résumé
Constitutive expression of major histocompatibility complex class II genes is acquired very early in B-cell ontogeny and is maintained up to the B-cell blast stage. Terminal differentiation in plasma cells is, however, accompanied by a loss of class II gene expression. In B cells this gene system is under the control of several loci encoding transacting factors with activator function, one of which, the aIr-1 gene product, operates across species barriers. In this report human class II gene expression is shown to be extinguished in somatic cell hybrids between the human class II-positive B-cell line Raji and the mouse class II-negative plasmacytoma cell line P3-U1. Since all murine chromosomes are retained in these hybrids and no preferential segregation of a specific human chromosome is observed, the results are compatible with the presence of suppressor factors of mouse origin, operating across species barriers and inhibiting class II gene expression. Suppression seems to act at the level of transcription or accumulation of class II-specific mRNA, since no human, and very few murine, class II transcripts are detectable in the hybrids.
Mots-clé
Animals, B-Lymphocytes, Burkitt Lymphoma, Cell Differentiation, Gene Expression Regulation, Genes, MHC Class II, Histocompatibility Antigens Class II, Humans, Hybrid Cells, Mice, Phenotype, Plasma Cells, Plasmacytoma, Transcription Factors, Tumor Cells, Cultured
Pubmed
Création de la notice
22/05/2009 9:52
Dernière modification de la notice
03/03/2018 16:25
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