Non-functioning pituitary carcinoma

Détails

ID Serval
serval:BIB_3F4F0E039D02
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Non-functioning pituitary carcinoma
Périodique
Pituitary
Auteur(s)
Imboden  P. N., Borruat  F. X., De Tribolet  N., Meagher-Villemure  K., Pica  A., Gomez  F.
ISSN
1386-341X (Print)
Statut éditorial
Publié
Date de publication
2004
Volume
7
Numéro
3
Pages
149-56
Notes
Case Reports
Journal Article
Résumé
Null-cell carcinomas of the pituitary are extremely rare. We describe a 41-year-old woman with a large adenohypophyseal neoplasm presenting as a primary nonfunctioning tumor without pituitary insufficiency. Signs of mass effect with progressive unilateral ocular motility disorders and anterior pituitary failure developed rapidly. Histopathological examination of the trans-sphenoidally removed tumor showed a primary pituitary null cell tumor with high mitotic index. Pituitary carcinoma was suspected because of rapid relapse of ocular motility disorders and of intra-sellar tumor growth after surgery. Radiotherapy of the sellar and parasellar area with a total dose of 59.4 Gy was performed, achieving marked tumor reduction and a significant improvement of ocular motility disorders. However, 6.5 months after presentation the patient rapidly declined and died of carcinomatous meningitis.Less than 100 pituitary carcinomas have been published so far, most of them as single-case reports, and endocrine, immunohistochemical, and ultrastructural data have not been described in the majority of cases. At presentation, there are no specific symptoms that allow to distinguish benign from malignant tumor. Prognosis is poor, since no curative treatment has been established, but aggressive surgery and radiotherapy has been recommended. Our case highlights the poor prognosis of nonfunctioning pituitary carcinomas.
Mots-clé
Adult Combined Modality Therapy Fatal Outcome Female Humans Hypopituitarism/*diagnosis/physiopathology Immunohistochemistry Magnetic Resonance Imaging Meningitis/etiology Ocular Motility Disorders/physiopathology Pituitary Gland, Anterior/chemistry/pathology/radiation effects Pituitary Hormones, Anterior/analysis Pituitary Neoplasms/*diagnosis/pathology/physiopathology/therapy Radiotherapy
Pubmed
Création de la notice
28/01/2008 12:37
Dernière modification de la notice
20/08/2019 13:36
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