Role of the gene Miniature in Drosophila wing maturation.

Détails

Ressource 1Télécharger: BIB_3F38D36D9709.P001.pdf (1351.16 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_3F38D36D9709
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Role of the gene Miniature in Drosophila wing maturation.
Périodique
Genesis
Auteur(s)
Bilousov O.O., Kozeretska I.A., Katanaev V.L.
ISSN
1526-968X (Electronic)
ISSN-L
1526-954X
Statut éditorial
Publié
Date de publication
2012
Volume
50
Numéro
7
Pages
525-533
Langue
anglais
Notes
Publication types: Letter
Résumé
Miniature is an extracellular zona pellucida domain-containing protein, required for flattening of pupal wing epithelia in Drosophila. Here, we show that Miniature also plays an important role in the post-eclosion wing maturation processes triggered by the neurohormone bursicon. Wing expansion and epithelial apoptosis are drastically delayed in miniature loss-of-function mutants, and sped up upon overexpression of the protein in wings. Miniature acts upstream from the heterotrimeric Gs protein transducing the bursicon signal in wing epithelia. We propose that Miniature interacts with bursicon and regulates its diffusion through or stability within the wing tissue.
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/08/2012 11:19
Dernière modification de la notice
08/05/2019 17:32
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